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Erythronolide synthase : ウィキペディア英語版 | Erythronolide synthase
In enzymology, an erythronolide synthase () is an enzyme that catalyzes the chemical reaction :6 malonyl-CoA + propanoyl-CoA 7 CoA + 6-deoxyerythronolide b Thus, the two substrates of this enzyme are malonyl-CoA and propanoyl-CoA, whereas its two products are CoA and 6-deoxyerythronolide b. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:propanoyl-CoA malonyltransferase (cyclizing). Other names in common use include erythronolide condensing enzyme, and malonyl-CoA:propionyl-CoA malonyltransferase (cyclizing). This enzyme participates in biosynthesis of 12-, 14- and 16-membered macrolides. ==Structural studies==
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , and .
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